@article{Mykhailiuk20134066,
title = {1-Amino-4,4-difluorocyclohexanecarboxylic acid as a promising building block for drug discovery: Design, synthesis and characterization},
author = {Mykhailiuk, P K and Starova, V and Iurchenko, V and Shishkina, S V and Shishkin, O V and Khilchevskyi, O and Zaporozhets, O},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84876140168&partnerID=40&md5=a58c4d8c57c15ab17416c7fec8edf16a},
year = {2013},
date = {2013-01-01},
journal = {Tetrahedron},
volume = {69},
number = {20},
pages = {4066--4075},
abstract = {1-Amino-4,4-difluorocyclohexanecarboxylic acid has been designed as a fluorinated analogue of the pharmacologically relevant 1- aminocyclohexanecarboxylic acid. The synthesis has been performed in three steps from a commercially available material in 22% overall yield. An impact of fluorine atoms on conformation, lipophilicity, acidity and fluorescent properties of the amino acid has been studied. Various practical applications of the obtained compound are suggested. © 2013 Elsevier Ltd. All rights reserved.},
keywords = {1 amino 4, 4 difluorocyclohexanecarboxylic acid; 1 aminocyclo, acidity; article; chemical analysis; commercial p, article},
pubstate = {published},
tppubtype = {article}
}