@article{Shcherbatiuk20133796,
title = {Synthesis of 2- and 3-trifluoromethylmorpholines: Useful building blocks for drug discovery},
author = {Shcherbatiuk, A V and Shyshlyk, O S and Yarmoliuk, D V and Shishkin, O V and Shishkina, S V and Starova, V S and Zaporozhets, O A and Zozulya, S and Moriev, R and Kravchuk, O and Manoilenko, O and Tolmachev, A A and Mykhailiuk, P K},
url = {http://www.scopus.com/inward/record.url?eid=2-s2.0-84875960686&partnerID=40&md5=e6e499585a09204c5c7e2ec535c48a66},
year = {2013},
date = {2013-01-01},
journal = {Tetrahedron},
volume = {69},
number = {19},
pages = {3796--3804},
abstract = {2- and 3-Trifluoromethylmorpholines were prepared in racemic and optically active forms. The synthesis commenced from the commercially available 2-trifluoromethyloxirane. The elaborated procedures were scalable, and the products were obtained in multigram quantities. The obtained compounds were comprehensively characterized by crystallographic analysis, fluorescence measurements, solubility, pKa, logD parameters, and clearance rate. The potential of the synthesized amines as the building blocks for drug discovery is thus demonstrated.© 2013 Elsevier Ltd. All rights reserved.},
keywords = {2 trifluoromethylmorpholine; 3 trifluoromethylmorp, animal tissue; article; chemical structure; cis t, article},
pubstate = {published},
tppubtype = {article}
}